Endocrine Abstracts

Background: In Pathogenesis of Neurodegeneration in Diabetes Mellitus (DM) addition to insulin resistance, glycemic control and blood plasma lipid levels existing other mechanisms were proposed. We investigated plasma insulin level in patients according to severity of diabetic neuropathy.Materials and methods: In 32 people with DM2 glycemia, HbA1c, blood plasma insulin, blood total cholesterol, triglycerides, Low Density Lipoproteins (LDLP) levels were m...

Damages of the central and peripheral nervous systems as peripheral neuropathy and encephalopathy of mixed vascular and metabolic genesis, respectively, are known to take place in diabetes mellitus, ultimately resulting in progressing decline of cognitive function and development of dementia. Findings of many studies demonstrated interrelation between increases in the TNF-α concentrations and onset of inflammation, tumor processes and a number of metabolic, autoimmune and...